Relationships between PTMs and disease, classified into 6 classes:

Dot size in the table (left) represents the number of PTM disease associated events:

Upregulation (U): the PTM level is upregulated in diseases.

Down-regulation (D): the PTM level is down-regulated in diseases.

Presence (P): the presence of a PTM event is associated with disease progression.

Absence (A): the absence of a PTM event is involved in disease progression.

Creation (C): a mutation event (single amino acid or indel mutations) creates one or multiple PTM sites or increases the protein PTM level in diseases.

Disruption (N): a mutation event that dis-rupts one or multiple PTM sites or reduces the protein PTM levels in diseases.

Types U and D focuses on the changes of PTM levels in disease tissue as compared to normal tissues

Types P and A shows whether presence or absence of a PTM event is associated with disease progression.

Types C and N relates to mutation driven PTM events in disease.